Given the Fantastic Four's close relationship with Uatu and the Watchers, I sincerely hope they will be involved in this "Original Sin" event you have coming up. He's a long-time and close friend to the team and it's hard for me to see any situation in which they would not want to be involved in investigating this. If they don't take an active role, I hope they are at least addressed in a meaningful manner. Character and history-wise it makes sense.