I’m not sure i quite see the difference that you’re pointing to. Avengers have appeared a whole bunch on X-Men, and X-Men have appeared in Avengers, and so forth. But that said, with a solo character like Spidey (one who has a regular team-up title to boot) it’s perhaps a bit easier to have characters interact. When you’re beginning your story with a dozen Avengers or X-Men, more characters will just make the story more crowded, not necessarily better.
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