New Brevoort Formspring

If you want to get into comics from manga, where do you start? With manga it has always been straightforward: you start with volume 1 and then go on to volume 2 and so on. But with comics you have volumes (which is more like arcs from what I gather) and then you have the issue number, but then there is also spin-offs and tie-ins. The comics that seem most interesting to me is the X-men series (because it has a large host of characters with different powers which I like) but where should I start?